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CDC - Isocyanates - NIOSH Workplace Safety and Health Topic

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Isocyanates are a family of extremely reactive, low unit importance chemicals. They are widely second hand in the manufacture of versatile and rigid foams, fibers, coatings such as paints and varnishes, and elastomers, and are more and more used in the travel industry, autobody repair, and building insulation materials. Spray-on polyurethane products containing isocyanates have been developed for a deep reach of retail, commercial, and blue-collar uses to defend cement, wood, fiberglass, weapon system and aluminum, including custodial coatings for cart beds, trailers, boats, foundations, and decks.

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Development of a respiratory sensitization/elicitation protocol of toluene diisocyanate (TDI) in Brown Norway rats to derive an elicitation-based occupational exposure level - ScienceDirect

)-response relationship on elicitation-based endpoints. The major goal of study was to fix the stimulant inhalation first medicament in sensitized, re-challenged Brown norge rats, including the related to variables moving the dosimetry of inhaled TDI-vapor in rats and as to how these differences can be translated to humans. Attempts were successful to reduplicate at least some traits of human bronchial asthma by using skin-sensitized rats which were subjected to single or bigeminal inhalation-escalation bid exposures. Two types of dose-escalation protocols were used to set the elicitation-threshold was based an ancillary pre-studies.

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